How would you answer this question?
How long can dyspepsia persist after the discontinuation of proton-pump inhibitors?
a. Three weeks
b. Twelve days
c. Twenty-four hours
d. Six months
The correct answer is "a" three weeks.
Proton pump inhibitors (PPIs) are a class of medication that decreases the transport of acid into the stomach, thus lessening symptoms of dyspepsia (heart burn), abdominal pain, and risk for gastric bleeding. Commonly used to treat active gastrointestinal bleeding, PPIs are also used extensively in the hospital setting to prevent ulcers. Upon discharge from the hospital, PPIs are often suddenly withdrawn and the patient may experience symptoms of the withdrawal of medication.
In a study by Niklasson, et al. (2010), the authors found that after discontinuing proton-pump inhibitors, "withdrawal symptoms" such as dyspepsia could last up to three weeks. Patients who take PPIs should be warned about the possibility of dyspepsia after discontinuation, and that the symptoms will resolve in about three weeks. Diet teaching to avoid spicy foods, caffeine, and alcohol may be helpful to minimize symptoms of withdrawal.
From: Niklasson, A., et al. (2010). Dyspeptic syndrome development after the discontinuation of a proton-pump inhibitor. Am. Journal of Gastroenterology, 105, 1531.
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